Online Management of Breast Diseases Patient Education |  Physician Guidelines |  Treatment Index
News |  TransMed |  E-Mail |  Disclaimer

STAGE IV - Breast Carcinoma

 
 
STAGE I V - BREAST CARCINOMA
THERAPEUTIC OPTIONS
 
BREAST CARCINOMA STAGE IV (Advanced)
TMN Classification

T4NO-3M0

T1-4N3M0

Cell Type All
Description
Any Tumor Size with or without
Lymph Node Metastasis
with Distant Metastasis (Liver,Bone,Brain,etc.)
 
  • LOCAL/SURGICAL MANAGEMENT
 
Mandatory Surgical Maneuver : FNA or Incisional Biopsy Only
Reference Studies: Need ER-PR Status of tumor
 
Therapeutic Options for Local Palliation / Control: Surgery and External Beam Radiation
Reference Studies: Local control and bone and visceral metastasis
 
  • SYSTEMIC TREATMENT: CHEMOTHERAPEUTIC & HORMONAL PROTOCOLS
   
RECOMMENDATION FOR STAGE IV

ER/PR POSITIVE

TMN Classification T0-4N0-3M1
Description
Any Tumor Size
with or without Lymph Node Metastasis and
Distant Metastasis
Recommendation
  • FOR BONE DISEASE ONLY: RECOMMEND HORMONAL THERAPY ONLY
  • FOR VISCERAL INVOLVEMENT (i.e. BRAIN,LIVER,LUNG, ETC.): RECOMMEND CHEMOTHERAPY INITIALLY IF PATIENT CAN TOLERATE; OTHERWISE RECOMMEND HORMONAL THERAPY
RECOMMENDED HORMONAL PROTOCOLS
OOPHORECTOMY TAMOXIFEN ARIMEDEX
RECOMMENDED CHEMOTHERAPEUTIC PROTOCOLS
CLICK ON EACH PROTOCOL
FOR DETAILED INFORMATION
ADRIAMYCIN

CYTOXAN

& TAMOXIFEN

aka: AC-T

CYTOXAN

METHOTREXATE

5FU

& TAMOXIFEN

aka: CMF-T

ORAL CYTOXAN

METHOTREXATE

5FU

& TAMOXIFEN

aka: Classic CMF-T

5FU

ADRIAMYCIN

CYTOXAN

& TAMOXIFEN

aka: FAC-T

NOTE:
 
RECOMMENDATION FOR STAGE IV

ER/PR NEGATIVE

TMN Classification T0-4N0-3M1
Description
Any Tumor Size
with or without Lymph Node Metastasis and
Distant Metastasis
RECOMMENDED CHEMOTHERAPEUTIC PROTOCOLS
CYTOXAN

METHOTHREXATE

5FU

PREDNISONE

aka: CMFP

CYTOXAN

METHOTHREXATE

5FU

VINCRISTINE

PREDNISONE

aka: CMFVP

ADRIAMYCIN

CYTOXAN

aka: AC

CYTOXAN

METHOTREXATE

5FU

aka: CMF

ORAL CYTOXAN

METHOTREXATE

5FU

aka: Classic CMF

5FU

ADRIAMYCIN

CYTOXAN

aka: FAC

 
 
 
 

Copyright 1997 - TransMed Network