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STAGE IIIB - Breast Carcinoma

 
 
STAGE I I I B - BREAST CARCINOMA
THERAPEUTIC OPTIONS
 
BREAST CARCINOMA STAGE III B (Locally Advanced)
TMN Classification

T4NO-3M0

T1-4N3M0

Includes Inflammatory Carcinoma

Cell Type All
Description
Any Tumor Size with chest wall involvement
with or without Lymph Node Metastasis or
Any Tumor Size with cancerous Lymph nodes
beneath the sternum
 
  • LOCAL/SURGICAL MANAGEMENT
 
Surgical Therapeutic Option 1: FNA or Incisional Biopsy (Systemic Chemo and Hormonal Rx) with Palliative Local External Beam Radiation
Indication Biopsy needed for ER-PR Status / External beam radiation for local palliation.
 
Surgical Therapeutic Option 2: FNA or Incisional Biopsy (Systemic Chemo and Hormonal Rx) with delayed Mastectomy or Lumpectomy with Axillary Dissection
Indication Biopsy needed for ER-PR Status / Mastectomy for local control (so-called toilet mastectomy)
 
  • SYSTEMIC TREATMENT: CHEMOTHERAPEUTIC & HORMONAL PROTOCOLS
   
RECOMMENDATION FOR STAGE IIIB

LYMPH NODES POSITIVE OR NEGATIVE- ER/PR POSITIVE OR NEGATIVE

TMN Classification T4N0-3M0 or T1-4N3M0
Description
Any Tumor Size with chest wall involvement
with or without Lymph Node Metastasis
or
Any Tumor Size with cancerous Lymph nodes
beneath the sternum
Recommendation CHEMOTHERAPY RECOMMENDED - HORMONAL THERAPY RECOMMENDED FOR ER/PR POSITIVE PATIENTS
RECOMMENDED CHEMOTHERAPEUTIC PROTOCOLS
CLICK ON EACH PROTOCOL
FOR DETAILED INFORMATION
ADRIAMYCIN

CYTOXAN

& TAMOXIFEN

aka: AC-T

CYTOXAN

METHOTREXATE

5FU

& TAMOXIFEN

aka: CMF-T

ORAL CYTOXAN

METHOTREXATE

5FU

& TAMOXIFEN

aka: Classic CMF-T

5FU

ADRIAMYCIN

CYTOXAN

& TAMOXIFEN

aka: FAC-T

  • All patients with large tumors should be considered for neoadjuvant treatment.
  • Patients with inflammatory carcinoma should be considered for autologous transplant when initial therapy is completed.
  • Patients with inflammatory carcinoma should be considered for neoadjuvant chemotherapy.
 
 

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